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PtS group

​Group leader: Per thor Straten 

Our overall goal is to improve immunotherapy of cancer. Key areas of our work are exercise immuno-oncology and improving T cell functionality. ​

​​PtS Group pursues its main goal through two main research areas:

1. Immunological effects of exercise 
We and others have shown that exercise reduces incidence and increase immunological growth control of several tumor types in mice.

Thus, our group is interested in uncovering the immunological mechanisms mediated by exercise to improve efficacy of current cancer therapies. Our research is grouped in three main areas:

  1. In vitro - the role of acute and chronic stress signals on immune cell function
  2. In vivo – tumor models of exercising mice testing exercise in combination with immunotherapy
  3. Clinical studies – the effects of high-intensity exercise on the immune responses in healthy individuals (INHALE) and NSCLC patients (HI AIM), and resistance training in metastatic prostate cancer patients (HIPimmune)

2. Fitter T cells, Better Immunotherapy
T cell functionality is a key parameter in successful immunotherapy against cancer. We have recently shown that MerTK – a member of the tyrosine receptor family TAM, acts as a co-stimulatory molecule on T cells. 

We aim to unravel how MerTK impact on T cell function, and study how cancer cells may jeopardize MerTK signaling to T cells.

Our areas of interest include:
  1. The co-stimulatory role of PROS1-mediated MerTK signaling in CD8 T cells
  2. The role of MerTK in CD4 T cell function 
  3. The role of MerTK in T cell/cancer cell interactions​.

​

​See current team members.​

​

Jürgen C. Becker, Essen University, Germany


Sebastian Kobold, Munich University, Germany

Viktor Umansky, German Cancer Research Center (DKFZ), Heidelberg, Germany

Reno Debets, Erasmus MC Cancer Institute, Rotterdam, Netherlands

Claus Desler, Center for Healthy Ageing, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark

Marta Kramer Mikkelsen & Dorte Nielsen, Dept Oncology, University Hospital Herlev, Denmark

Lars Rønn, DTU, Denmark

Søren Skov, University of Copenhagen, Denmark

Daniel H. Madsen, CCIT-DK, University Hospital Herlev, Denmark

Mads Hald Andersen, CCIT-DK, University Hospital Herlev, Denmark​


​You can send an unsolicited application to ccit-dk.herlev-og-gentofte-hospital@regionh.dk if interested in working in the PtS group.​

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