The exact pathophysiology behind Tourette syndrome is not yet known, but there is evidence for a genetic etiology. Tourette syndrome has a complex mode of inheritance in which both genetic and environmental factors are believed to be involved in disease development. Different approaches to identify genes associated to Tourette syndrome have led to the discovery of several candidate genes. However, none of these has been shown to be major causative genes associated with the development of Tourette syndrome.
Monozygotic twins have exactly the same genes, while dizygotic twins have the same genes in common as first-grade family members have. Therefore, twin studies are important in disentangling the genetic cause of Tourette syndrome.
We include all Danish twin pairs from the National Twin Register, with at least one of the pair having tics or Tourette syndrome. Participants will get taken blood samples for genetic analyses and examined by several diagnostic instruments to assess the presence of comorbidity. Furthermore, we will include the parents and selected family members, if possible, who will get taken blood samples for genetic analyses.
Our aim is to increase knowledge about the heredity of Tourette syndrome, which will contribute to a better understanding of the syndrome and more targeted genetic counseling. Results of the study could also lead to the development of new treatment options.
From 2016 and ongoing
Ongoing application to funds