The exact pathophysiology behind Tourette syndrome is not yet known, but there is evidence for a genetic etiology. Tourette syndrome has a complex mode of inheritance in which both genetic and environmental factors are believed to be involved in disease development. Different approaches to identify genes associated to Tourette syndrome have led to the discovery of several candidate genes. However, none of these has been shown to be major causative genes associated with the development of Tourette syndrome. It is therefore important to include as many patients as possible in genetic analyzes and also their parents, siblings and other family members.
In this study, all patients diagnosed with Tourette syndrome and selected family members are included in this project. Blood samples will be taken for genetic analyses. Our aim is to increase knowledge about the heredity of TS, which will contribute to a better understanding of the syndrome and more targeted genetic counseling. Results of the study could also lead to the development of new treatment options.
Start 2005, ongoing.
Lundbeck Foundation, Ongoing application to funds.