In recent years, several neuropsychiatric diseases have been suggested to have an autoimmune and post-infectious etiology. One example is PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections), which is defined as sudden onset autoimmune disease with obsessive compulsive disorder (OCD) and/or tics associated with group A beta-hemolytic streptococcus infection.
EMTICS is a European Multicenter Tics Study that aims to identify the genetic and environmental susceptibility factors of tic disorders and to contribute to a better understanding of the underlying mechanisms, especially by elucidating the role of autoimmunity and infections.
Two groups have been included: 1) A group with siblings who were included into the project when they debuted with tics; and 2) A group of patients with Tourette syndrome, who were examined during a period of exacerbation of tics.
Participants have been examined with throat culture, various blood samples and genetic analyses.
Inclusion of participants stopped in January 2018, analyses of results are ongoing.