The project

In recent years, several neuropsychiatric diseases have been suggested to have an autoimmune and post-infectious etiology. One example is PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections), which is defined as sudden onset autoimmune disease with obsessive compulsive disorder (OCD) and/or tics associated with group A beta-hemolytic streptococcus infection. 

EMTICS is a European Multicenter Tics Study that aims to identify the genetic and environmental susceptibility factors of tic disorders and to contribute to a better understanding of the underlying mechanisms, especially by elucidating the role of autoimmunity and infections. 

Two groups have been included: 1) A group with siblings who were included into the project when they debuted with tics; and 2) A group of patients with Tourette syndrome, who were examined during a period of exacerbation of tics.
Participants have been examined with throat culture, various blood samples and genetic analyses. 

Time frame

Inclusion of participants stopped in January 2018, analyses of results are ongoing.


EU programme EP7