The department has its own Research Laboratory, a facility accommodating dedicated junior and senior researchers. Based on clinical problems the overarching aim of the Research Laboratory is to uncover the most basic pathophysiological elements of a range of gastrointestinal (GI) disorders, especially inflammatory bowel disease (IBD), by applying advanced molecular biological techniques in collaboration with other academic partners. These efforts will hopefully influence the future management of IBD and thus the quality of life for this otherwise tormented patient population.
With the present knowledge at hand there is an evident need for increased insight into the pathophysiology, for developing simple and more accurate diagnostic tools, and a need for means of identifying the clinically evident phenotypes, and hence be able to achieve personalized medical care and treatment tailored to the genetic makeup and biology of patients with IBD at an early stage.
In the Research Laboratory we have extensive expertise working with various molecular techniques such as ELISA (simplex and multiplex), western blotting, quantitative PCR and RT-PCR, chromatin immunoprecipitation, cell transfection, immunohistochemical staining, high-performance liquid chromatography (HPCL), and flow cytometry. These techniques are applied on cells purified from samples collected from patients with IBD (intestinal tissue and blood) which we are able to short- or long-term maintenance as cultures. Moreover, we have several commercially available human cell lines such as Caco2, HT29, DLD1, SW480 and THP1 running in the laboratory to do some functional analyses.
Furthermore, the Research Laboratory is a central part of several clinical studies in collaboration with medical companies where the role of the Research Laboratory is to perform the coordination, maintenance and analysis of patient samples.